Thomas Little came from Devonshire, England, and is first recorded in Plymouth, MA, on the tax list of 25 March 1633. He sold his dwelling house to Richard Higgins for twenty-one bushels of corn on 7 October 1633. He made a gift of land to his brother-in-law, Robert Bartlett, on 28 May 1635. He received the transfer of the indenture of William Taylor from Mr. John Atwood on 12 March 1638/9. He moved to Marshfield where he became constable on 3 June 1662. He bought farm land which had belonged to Maj. William Holmes, deceased, which he improved. On 3 June 1662, the court ruled that in view of his many improvements, if anyone should show better title to the land in the future, such person would have to pay him fully for his improvements. When he refused to pay rents for this land claimed by Mrs. Rachel Davenport, the court on 1 May 1666 awarded her less money than she had claimed because of his improvements.

Thomas and his wife Anna (Warren) Little had nine children, the first seven born in Plymouth, the last two in Marshfield, MA:

• Abigail, b. ca. 1635; m. Josiah Keen.
• Ruth, probably unmarried.
• Hannah, b. ca. 1636/7; m. Stephen Tilden.
• Patience, b. ca. 1639; m. Joseph Jones.
• Mercy, b. ca. 1645; m. John Sawyer.
• Isaac, b. ca. 1646; m. Bethiah Thomas.
• Ephraim, b. May 1650; m. Mary Sturtevant.
• Thomas, b. ca. 1654; killed by Indians in King Philip's War, 1676.
• Samuel, b. ca. 1656; m. Sarah Gray.